I’ve done it — San Diego to Cabo San Lucas — in a 1965 Land Rover 109, right-hand drive. Of course that was about twenty years ago.
It was a great trip, and Mexico is a lot safer than the US in many ways.
A few things I learned:
Get Mexican insurance. If you get in an accident and don’t have insurance, you go to jail.
Plan on the trip taking several days. It’s around 1,000 miles, and 250 miles per day is a long driving day, especially if you stop for tacos or to enjoy the scenery and the beaches along the way. Which you should, since that’s the best part.
Drive slower than the speed limit. Speeds are in kilometers. So 35k is like 20mph. 70 is 40. 100 is 60.
Don’t drive at night.
When cars or trucks are coming in the other direction, hug the right side of the highway, but don’t go off the edge because it’s often soft sand.
Hotels are cheap, but not as clean and shiny as American hotels. If you want a fancy hotel, book one in Cabo.
I slept in the back of the car, which worked out well most of the time. Usually I was in a campground — there are a lot of them. Other times I just pulled down a dirt road to the beach.
Be prepared to be searched, usually by the military. If you’d like, carry some cold sodas to give to the officers after they’ve searched you. They love that.
Do not carry drugs of any kind — except prescription drugs, and you should have your name on the bottle.
If you take a dog, be sure you have its papers.
Try not to bribe officials, if you can avoid it.
Get the AAA guide to Baja.
The right-hand drive added a certain element to passing other vehicles, since I was on the wrong side of the car to see oncoming traffic. But the Land Rover felt completely at home down there. That’s what it was built for.